Article
Organophosphate and pyrethroid hydrolase activities of mutant Esterases from the cotton bollworm Helicoverpa armigera.
PloS one - 1 Jan 2013
Li Yongqiang, Farnsworth Claire A, Coppin Chris W, Teese Mark G, Liu Jian-Wei, Scott Colin, Zhang Xing, Russell Robyn J, Oakeshott John G
Abstract excerpt
Two mutations have been found in five closely related insect esterases (from four higher Diptera and a hymenopteran) which each confer organophosphate (OP) hydrolase activity on the enzyme and OP resistance on the insect. One mutation converts a Glycine to an Aspartate, and the other converts a Tryptophan to a Leucine in the enzymes' active site. One of the dipteran enzymes with the Leucine mutation also shows...
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