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Comparing the organophosphorus and carbamate insecticide resistance mutations in cholin- and carboxyl-esterases.

Chemico-biological interactions - 15 Dec 2005

Oakeshott John G, Devonshire Alan L, Claudianos Charles, Sutherland Tara D, Horne Irene, Campbell Peter M, Ollis David L, Russell Robyn J

Abstract excerpt

Mutant insect carboxyl/cholinesterases underlie over 60 cases of resistance to organophosphorus and/or carbamate insecticides. Biochemical and molecular data on about 20 of these show recurrent use of a very small number of mutational options to generate either target site or metabolic resistance. Moreover, the mutant enzymes are often kinetically inefficient and associated with significant fitness costs, due to...

Topics

Animals
Carbamates
Carboxylesterase
Cholinesterase Inhibitors
Cholinesterases
Insecta
Insecticide Resistance
Insecticides
Mites
Mutation
Organophosphorus Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16289012
DOI: 10.1016/j.cbi.2005.10.041

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