A genome-wide survey of transgenerational genetic effects in autism.

doi:10.1371/journal.pone.0076978

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Article

A genome-wide survey of transgenerational genetic effects in autism.

PloS one - 1 Jan 2013

Tsang Kathryn M, Croen Lisa A, Torres Anthony R, Kharrazi Martin, Delorenze Gerald N, Windham Gayle C, Yoshida Cathleen K, Zerbo Ousseny, Weiss Lauren A

Abstract excerpt

Effects of parental genotype or parent-offspring genetic interaction are well established in model organisms for a variety of traits. However, these transgenerational genetic models are rarely studied in humans. We have utilized an autism case-control study with 735 mother-child pairs to perform genome-wide screening for maternal genetic effects and maternal-offspring genetic interaction. We used simple models of...

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