Article
A unified genetic theory for sporadic and inherited autism.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2007
Zhao Xiaoyue, Leotta Anthony, Kustanovich Vlad, Lajonchere Clara, Geschwind Daniel H, Law Kiely, Law Paul, Qiu Shanping, Lord Catherine, Sebat Jonathan, Ye Kenny, Wigler Michael
Abstract excerpt
Autism is among the most clearly genetically determined of all cognitive-developmental disorders, with males affected more often than females. We have analyzed autism risk in multiplex families from the Autism Genetic Resource Exchange (AGRE) and find strong evidence for dominant transmission to male offspring. By incorporating generally accepted rates of autism and sibling recurrence, we find good fit for a...
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