Article
Involvement of parental imprinting in the antisense regulation of onco-miR-372-373.
Nature communications - 1 Jan 2013
Stelzer Yonatan, Sagi Ido, Benvenisty Nissim
Abstract excerpt
The monoallelic nature of imprinted genes renders them highly susceptible to genetic and epigenetic perturbations, potentially resulting in transformation and disease. Here we show, using parthenogenetic induced pluripotent stem cells, an imprinted transcript that serves as an antisense regulator of onco-miR-372-3 (named anti-miR-371-3). As miR-372-3 have been shown to have an oncogenic role in testicular germ...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.