Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics

18 Jan 2024

Abstract excerpt

To explore the molecular network mechanism of Celastrol in the treatment of rheumatoid arthritis (RA) based on a novel strategy (integrated systems pharmacology, proteomics, transcriptomics and single-cell transcriptomics). Firstly, the potential targets of Celastrol and RA genes were predicted through the database, and the Celastrol-RA targets were obtained by taking the intersection. Then, transcriptomic data...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to interferon and immune responses
Share to Natural Compounds in Disease Treatment
Share to Rheumatoid Arthritis Research and Therapies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38238321
DOI: 10.1038/s41598-023-48248-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omicsPMID 38238321Read ↗

Potential mechanisms of action of celastrol against rheumatoid arthritis: transcriptomic and proteomic analysisSemantic proximity Read ↗

Potential mechanisms of action of celastrol against rheumatoid arthritis: transcriptomic and proteomic analysisSemantic proximity Read ↗

Comparative transcriptomics and network pharmacology analysis to identify the potential mechanism of celastrol against osteoarthritisSemantic proximity Read ↗

IDENTIFICATION OF IMMUNE RESPONSE AND RNA NETWORK OF RHEUMATOID ARTHRITIS AND MOLECULAR DOCKING OF <i>CELASTRUS PANICULATUS</i> AS POTENTIAL THERAPEUTIC AGENTSemantic proximity Read ↗

Integrative Multi-Omics and In Silico Computational Analysis Revealed, Marine-Derived Compounds as Potential Therapeutics Targeting Key Regulatory Genes in Rheumatoid ArthritisSemantic proximity Read ↗

Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental ValidationSemantic proximity Read ↗

Exploring potential network pharmacology-and molecular docking-based mechanism of melittin in treating rheumatoid arthritisSemantic proximity Read ↗

Bioinformatic analysis to find small molecules related to rheumatoid arthritis.Semantic proximity Read ↗

Quercetin is a Potential Therapy for Rheumatoid Arthritis via Targeting Caspase-8 Through Ferroptosis and PyroptosisSemantic proximity Read ↗

Exploring the Potential Mechanisms of Jintiange Capsule in Treating Rheumatoid Arthritis Based on Network Pharmacology and BioinformaticsSemantic proximity Read ↗

Serum proteomics analysis from rheumatoid arthritis patients receiving combination therapy of imrecoxib, total glucosides of paeony and two DMARDsSemantic proximity Read ↗

Identification of Potential Therapeutic Targets For Rheumatoid Arthritis By BioinformaticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.