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Article

Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation.

European journal of immunology - 1 Jan 2013

D'Orlando Orietta, Zhao Fang, Kasper Brigitte, Orinska Zane, Müller Jürgen, Hermans-Borgmeyer Irm, Griffiths Gillian M, Zur Stadt Udo, Bulfone-Paus Silvia

Abstract excerpt

Syntaxin 11 (STX11) controls vesicular trafficking and is a key player in exocytosis. Since Stx11 mutations are causally associated with a familial hemophagocytic lymphohistio-cytosis, we wanted to clarify whether STX11 is functionally important for key immune cell populations. This was studied in primary cells obtained from newly generated Stx11(-/-) mice. Our data revealed that STX11 is not only widely...

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Share to Cell Degranulation
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

Share to Lymphohistiocytosis, Hemophagocytic

Share to Munc18 Proteins

Share to Neutrophils

Share to Qa-SNARE Proteins

Share to Qb-SNARE Proteins

Source

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Identifiers

PMID: 23042080
DOI: 10.1002/eji.201142343
PMCID: PMC5405866

Genes

STX11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation.PMID 23042080Read ↗

Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defectSemantic proximity Read ↗

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cellsSemantic proximity Read ↗

Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.Semantic proximity Read ↗

Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes.Semantic proximity Read ↗

Syntaxin‐11 is expressed in primary human monocytes/macrophages and acts as a negative regulator of macrophage engulfment of apoptotic cells and IgG‐opsonized target cellsSemantic proximity Read ↗

Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients.Semantic proximity Read ↗

STX11 p.R129P variant correlate with an in vitro impairment in NK and CD8+ T-cell-mediated cytotoxicitySemantic proximity Read ↗

Syntaxin11 Deficiency Inhibits CRAC Channel Priming to Suppress Cytotoxicity and Gene Expression in T Lymphocytes Independent of Membrane TraffickingSemantic proximity Read ↗

Syntaxin binding mechanism and disease-causing mutations in Munc18-2Semantic proximity Read ↗

Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing.Semantic proximity Read ↗

Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11.Semantic proximity Read ↗

STX11 mutations and clinical phenotypes of familial hemophagocytic lymphohistiocytosis in North America.Semantic proximity Read ↗

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