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Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells

4 Nov 2013

Abstract excerpt

Hematopoietic stem and progenitor cells, as well as nucleated erythroblasts and megakaryocytes, reside preferentially in adult marrow microenvironments whereas other blood cells readily cross the endothelial barrier into the circulation. Because the nucleus is the largest organelle in blood cells, we hypothesized that (i) cell sorting across microporous barriers is regulated by nuclear deformability as controlled...

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PMID: 24191023
DOI: 10.1073/pnas.1304996110

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