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Thrombospondin-1 inhibits ADAMTS13 activity in sickle cell disease

1 Nov 2013

Abstract excerpt

Sickle cell disease (SCD) is characterized by increased cellular adhesiveness, hemolytic anemia, hemostatic activation, vaso-occlusion and thrombosis. We found that patients with SCD in steady state have elevated plasma levels of the platelet protein thrombospondin-1 (TSP1) and that these levels are associated with vaso-occlusive complications and a history of acute chest syndrome (ACS). 1

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Identifiers

PMID: 24186313
DOI: 10.3324/haematol.2013.092635

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