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Article

The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD.

Nature neuroscience - 1 Dec 2013

Suzuki Naoki, Maroof Asif M, Merkle Florian T, Koszka Kathryn, Intoh Atsushi, Armstrong Ian, Moccia Rob, Davis-Dusenbery Brandi N, Eggan Kevin

Abstract excerpt

Using transgenic mice harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog (3110043O21Rik). Unlike most genes that are mutated in amyotrophic lateral sclerosis (ALS), which are ubiquitously expressed, the C9ORF72 ortholog was most highly transcribed in the neuronal populations that are sensitive to degeneration in ALS and frontotemporal dementia. Thus, our results...

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Identifiers

PMID: 24185425
DOI: 10.1038/nn.3566
PMCID: PMC4397902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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