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Article

Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis

30 May 2013

Abstract excerpt

OBJECTIVE: To define the role that repeat expansions of a GGGGCC hexanucleotide sequence of the C9orf72 gene play in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). A genetic model for ALS was developed to determine whether loss of function of the zebrafish orthologue of C9orf72 (zC9orf72) leads to abnormalities in neuronal development. METHODS: C9orf72 mRNA...

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PMID: 23720273
DOI: 10.1002/ana.23946

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