Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The high cost of fidelity.

AIDS research and human retroviruses - 1 Jan 2014

Lloyd Sarah B, Kent Stephen J, Winnall Wendy R

Abstract excerpt

The notoriously low fidelity of HIV-1 replication is largely responsible for the virus's rapid mutation rate, facilitating escape from immune or drug control. The error-prone activity of the viral reverse transcriptase (RT) is predicted to be the most influential mechanism for generating mutations. The low fidelity of RT has been successfully exploited by nucleoside and nucleotide analogue reverse transcriptase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to Genetic Variation
Share to HIV-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to HIV Reverse Transcriptase

Share to Mutation Rate

Share to Reverse Transcriptase Inhibitors

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 24180375
DOI: 10.1089/AID.2013.0153
PMCID: PMC3887412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The high cost of fidelity.PMID 24180375Read ↗

Fidelity Variants and RNA Quasispecies.Semantic proximity Read ↗

The cost of replication fidelity in human immunodeficiency virus type 1.Semantic proximity Read ↗

Nucleoside-analog resistance mutations in HIV-1 reverse transcriptase and their influence on polymerase fidelity and viral mutation rates.Semantic proximity Read ↗

High fidelity simian immunodeficiency virus reverse transcriptase mutants have impaired replication in vitro and in vivo.Semantic proximity Read ↗

Interrelationship between HIV-1 fitness and mutation rate.Semantic proximity Read ↗

Thinking Outside the Triangle: Replication Fidelity of the Largest RNA VirusesSemantic proximity Read ↗

Molecular basis of fidelity of DNA synthesis and nucleotide specificity of retroviral reverse transcriptases.Semantic proximity Read ↗

Isolation of fidelity variants of RNA viruses and characterization of virus mutation frequency.Semantic proximity Read ↗

West Nile Virus fidelity modulates the capacity for host cycling and adaptation.Semantic proximity Read ↗

Recent advances in understanding HIV evolutionSemantic proximity Read ↗

Low-Fidelity Polymerases of Alphaviruses Recombine at Higher Rates To Overproduce Defective Interfering ParticlesSemantic proximity Read ↗

Implications of altered replication fidelity on the evolution and pathogenesis of coronavirusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.