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Article

High fidelity simian immunodeficiency virus reverse transcriptase mutants have impaired replication in vitro and in vivo.

Virology - 1 May 2016

Lloyd Sarah B, Lichtfuss Marit, Amarasena Thakshila H, Alcantara Sheilajen, De Rose Robert, Tachedjian Gilda, Alinejad-Rokny Hamid, Venturi Vanessa, Davenport Miles P, Winnall Wendy R, Kent Stephen J

Abstract excerpt

The low fidelity of HIV replication facilitates immune and drug escape. Some reverse transcriptase (RT) inhibitor drug-resistance mutations increase RT fidelity in biochemical assays but their effect during viral replication is unclear. We investigated the effect of RT mutations K65R, Q151N and V148I on SIV replication and fidelity in vitro, along with SIV replication in pigtailed macaques. SIVmac239-K65R and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26896929
DOI: 10.1016/j.virol.2016.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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