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Article

HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression

1 Jan 2013

Abstract excerpt

SNCA/α-synuclein and its rare mutations are considered as the culprit proteins in Parkinson disease (PD). Wild-type (WT) SNCA has been shown to impair macroautophagy in mammalian cells and in transgenic mice. In this study, we monitored the dynamic changes in autophagy process and confirmed that overexpression of both WT and SNCA(A53T) inhibits autophagy in PC12 cells in a time-dependent manner. Furthermore, we...

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PMID: 24178442
DOI: 10.4161/auto.26751

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