Article
GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A.
Autophagy - 1 Jan 2015
Du Ting-Ting, Wang Le, Duan Chun-Li, Lu Ling-Ling, Zhang Jian-Liang, Gao Ge, Qiu Xiao-Bo, Wang Xiao-Min, Yang Hui
Abstract excerpt
Loss-of-function mutations in the gene encoding GBA (glucocerebrosidase, β, acid), the enzyme deficient in the lysosomal storage disorder Gaucher disease, elevate the risk of Parkinson disease (PD), which is characterized by the misprocessing of SNCA/α-synuclein. However, the mechanistic link between GBA deficiency and SNCA accumulation remains poorly understood. In this study, we found that loss of GBA function...
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