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Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer

31 Oct 2013

Abstract excerpt

Autophagy (macroautophagy) is an evolutionarily conserved lysosomal degradation process, in which a cell degrades long-lived proteins and damaged organelles. Recently, accumulating evidence has revealed the core molecular machinery of autophagy in carcinogenesis; however, the intricate relationship between autophagy and cancer continue to remain an enigma. Why does autophagy have either pro-survival (oncogenic)...

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PMID: 24176850
DOI: 10.1038/cddis.2013.422

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