Article
Hepatitis C virus genotype 1: how genetic variability of the core protein affects the response to pegylated-interferon and ribavirin therapy.
Journal of medical virology - 1 Feb 2014
Alhamlan F S, Al-Ahdal M N, Khalaf N Z, Abdo A A, Sanai F M, Al-Ashgar H I, Elhefnawi M, Zaid A, Al-Qahtani A A
Abstract excerpt
Hepatitis C virus subgenotypes 1a and 1b are found worldwide and cause 60% of all hepatitis C cases. It has been reported recently that viral genetic variations have a critical impact on the patient treatment outcome. In particular, polymorphisms of the HCV core protein have been linked to poor treatment response. However, most of these studies were conducted on Asian populations, Japanese in particular who are...
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