Article
Potential pitfalls in the diagnosis of Hb Handsworth in areas with high prevalence of HbS.
International journal of laboratory hematology - 1 Aug 2014
Al Zadjali S, Al-Riyami A Z, Gravell D, Al Haddabi H, Al Rawahi M, Al Falahi K, Daar S
Abstract excerpt
Hb Handsworth is a rare α-globin structural variant caused by a missense mutation either on the α2 or α1-globin gene (HBA2 or HBA1: c.55G>C, p.Gly18Arg). This variant might be erroneously diagnosed as HbS unless secondary confirmative tests are carried out. We encountered a child with a prominent peak eluting in the 'S' window on high-performance liquid chromatography (HPLC). Sickle solubility test, gel...
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