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Article

Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations.

Journal of molecular biology - 23 Jan 2014

Blancas-Mejía Luis M, Tischer Alexander, Thompson James R, Tai Jonathan, Wang Lin, Auton Matthew, Ramirez-Alvarado Marina

Abstract excerpt

Light chain amyloidosis is a devastating disease where immunoglobulin light chains form amyloid fibrils, resulting in organ dysfunction and death. Previous studies have shown a direct correlation between the protein thermodynamic stability and the propensity for amyloid formation for some protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24157440
DOI: 10.1016/j.jmb.2013.10.016
PMCID: PMC3892967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24157440-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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