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Article

Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations.

Journal of molecular biology - 23 Jan 2014

Blancas-Mejía Luis M, Tischer Alexander, Thompson James R, Tai Jonathan, Wang Lin, Auton Matthew, Ramirez-Alvarado Marina

Abstract excerpt

Light chain amyloidosis is a devastating disease where immunoglobulin light chains form amyloid fibrils, resulting in organ dysfunction and death. Previous studies have shown a direct correlation between the protein thermodynamic stability and the propensity for amyloid formation for some proteins involved in light chain amyloidosis. Here we investigate the effect of somatic mutations on protein stability and in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24157440
DOI: 10.1016/j.jmb.2013.10.016
PMCID: PMC3892967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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