Concentration-resistance relationship and PK/PD evaluation of danofloxacin against emergence of resistant Pasteurella multocida in an in vitro dynamic model.

doi:10.1093/jambio/lxae154

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Article

Concentration-resistance relationship and PK/PD evaluation of danofloxacin against emergence of resistant Pasteurella multocida in an in vitro dynamic model.

Journal of applied microbiology - 2 Jul 2024

Lu Ting-Yin, Sun Zhen, Liang Liu-Yan, Zhang Jing, Guo Wen-Long, Wang Zi-Ye, Sun Jian, Liao Xiao-Ping, Zhou Yu-Feng

Abstract excerpt

AIMS: This study aimed to assess the pharmacokinetic/pharmacodynamic (PK/PD) targets of danofloxacin to minimize the risk of selecting resistant Pasteurella multocida mutants and to identify the mechanisms underlying their resistance in an in vitro dynamic model, attaining the optimum dosing regimen of danofloxacin to improve its clinical efficacy based on the mutant selection window (MSW) hypothesis. METHODS AND...

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PMID: 38925653
DOI: 10.1093/jambio/lxae154

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