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Article

Inhibition of p38 MAPK-dependent MutS homologue-2 (MSH2) expression by metformin enhances gefitinib-induced cytotoxicity in human squamous lung cancer cells.

Lung cancer (Amsterdam, Netherlands) - 1 Dec 2013

Ko Jen-Chung, Chiu Hsien-Chun, Wo Ting-Yu, Huang Yi-Jhen, Tseng Sheng-Chieh, Huang Yu-Ching, Chen Huang-Jen, Syu Jhan-Jhang, Chen Chien-Yu, Jian Yun-Ting, Jian Yi-Jun, Lin Yun-Wei

Abstract excerpt

OBJECTIVES: Gefitinib, a quinazoline-derived tyrosine kinase inhibitor, has anti-tumor activity in vivo and in vitro. Human MutS homologue-2 (MSH2) plays a central role in promoting genetic stability by correcting DNA replication errors. The present study investigated the effects of p38 mitogen-activated protein kinase (MAPK) signal on gefitinib-induced MSH2 expression in two human non-small cell lung squamous...

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Identifiers

PMID: 24138903
DOI: 10.1016/j.lungcan.2013.09.011

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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