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Article

Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance

13 Mar 2014

Abstract excerpt

In this in vitro study, we determined whether masitinib could reverse multidrug resistance (MDR) in cells overexpressing the ATP binding cassette subfamily G member 2 (ABCG2) transporter. Masitinib (1.25 and 2.5 µM) significantly decreases the resistance to mitoxantrone (MX), SN38 and doxorubicin in HEK293 and H460 cells overexpressing the ABCG2 transporter. In addition, masitinib (2.5 µM) significantly increased...

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PMID: 24626598
DOI: 10.3892/ijo.2014.2341

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