Article
The Arg64 allele of the beta 3-adrenoceptor gene but not the -3826G allele of the uncoupling protein 1 gene is associated with increased leptin levels in the Spanish population.
Metabolism: clinical and experimental - 1 Nov 2004
Ramis Joana Maria, González-Sánchez José Luis, Proenza Ana María, Martínez-Larrad María Teresa, Fernández-Pérez Cristina, Palou Andreu, Serrano-Ríos Manuel
Abstract excerpt
To determine whether there are variations in leptin levels according to the beta(3)-adrenoceptor (beta(3)-AR) Trp64Arg and uncoupling protein 1 (UCP1) -3826A-->G polymorphisms, given the regulatory role of catecholamines through the beta(3)-AR in leptin production and the previously reported association of the UCP1 -3826A-->G variant with obesity. A total of 160 men and 172 women randomly chosen from a nationwide...
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