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Article

Genetic background and window of exposure contribute to thyroid dysfunction promoted by low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice.

Scientific reports - 5 Nov 2018

Reale Carla, Porreca Immacolata, Russo Filomena, Marotta Maria, Roberto Luca, Russo Nicola Antonino, Carchia Emanuele, Mallardo Massimo, De Felice Mario, Ambrosino Concetta

Abstract excerpt

Genetic and environmental factors contribute to thyroid diseases. Although still debated, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is thought to induce thyroid dysfunction in humans and rodents. The data here reported point out the contribution of the exposure window and genetic background in mediating the low-dose TCDD effects on thyroid. Indeed, early (from E0.5 to PND30) and low-dose (0,001 μg/kg/day) TCDD...

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Identifiers

PMID: 30397221
DOI: 10.1038/s41598-018-34427-2
PMCID: PMC6218492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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