Article
Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells.
The Journal of biological chemistry - 22 Nov 2013
Yang Fu-Chia, Lin Ya-Huei, Chen Wei-Hao, Huang Jing-Yi, Chang Hsin-Yun, Su Su-Hui, Wang Hsiao-Ting, Chiang Chun-Yi, Hsu Pang-Hung, Tsai Ming-Daw, Tan Bertrand Chin-Ming, Lee Sheng-Chung
Abstract excerpt
Salt-inducible kinase 2 (SIK2) is an important regulator of cAMP response element-binding protein-mediated gene expression in various cell types and is the only AMP-activated protein kinase family member known to interact with the p97/valosin-containing protein (VCP) ATPase. Previously, we have demonstrated that SIK2 can regulate autophagy when proteasomal function is compromised. Here we report that physical and...
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