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Oral Administration of the carboxylic acid ester prodrug NHC SN_9 protects mice from lethal Orthopoxvirus challenge: Implications for the Treatment of Monkeypox

2026-01-02

Abstract excerpt

The global resurgence of monkeypox (Mpox) since 2022 has highlighted an urgent need for effective antiviral therapeutics against orthopoxvirus infections. While vaccines provide prophylactic protection, therapeutic options remain limited, particularly for immunocompromised individuals. Previously, we demonstrated potent antiviral activity of N4-hydroxycytidine (NHC) analogs against coronaviruses, including SARS-Co...

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Literature Corpus work
65a0ee55-eadd-5294-8fa8-8cf16194c219
DOI
10.64898/2025.12.30.696971
Open publication

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