Article
The CC16 A38G polymorphism is associated with asymptomatic airway hyper-responsiveness and development of late-onset asthma.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology - 1 Nov 2013
Taniguchi Natsuko, Konno Satoshi, Hattori Takeshi, Isada Akira, Shimizu Kaoruko, Shimizu Kenichi, Shijubo Noriharu, Huang Shau-Ku, Hizawa Nobuyuki, Nishimura Masaharu
Abstract excerpt
BACKGROUND: Clara cell secretory protein (CC16) is expressed primarily in the respiratory tract and is a potent anti-inflammatory agent that protects the airway from inflammation. The associations of the A38G polymorphism in this gene with asymptomatic airway hyper-responsiveness (AHR), which is considered a risk factor for future asthma in adults, and the development of adult-onset asthma are unclear. OBJECTIVE:...
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