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Article

Understanding the impact of 2D and 3D fibroblast cultures on in vitro breast cancer models.

PloS one - 1 Jan 2013

Sung Kyung Eun, Su Xiaojing, Berthier Erwin, Pehlke Carolyn, Friedl Andreas, Beebe David J

Abstract excerpt

The utilization of 3D, physiologically relevant in vitro cancer models to investigate complex interactions between tumor and stroma has been increasing. Prior work has generally focused on the cancer cells and, the role of fibroblast culture conditions on tumor-stromal cell interactions is still largely unknown. Here, we focus on the stroma by comparing functional behaviors of human mammary fibroblasts (HMFs)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24124550
DOI: 10.1371/journal.pone.0076373
PMCID: PMC3790689

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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