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Article

Small-molecule mechanism of action studies in Caenorhabditis elegans.

Chembiochem : a European journal of chemical biology - 25 Nov 2013

Zlotkowski Katherine, Eliasen Anders M, Mitra Aurpon, Siegel Dionicio

Abstract excerpt

A general protocol for exogenous small-molecule pull-down experiments with Caenorhabditis elegans is described; it provides a link between small-molecule screens in worms and existing mutant and RNAi technologies, thereby enabling organismal mechanism of action studies for the natural product clovanemagnolol. Forward chemical genetic screens followed by mechanism of action studies with C. elegans, when coupled...

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PMID: 24123757
DOI: 10.1002/cbic.201300399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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