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Article

Functional investigation of transmembrane helix 3 in H⁺-translocating pyrophosphatase.

The Journal of membrane biology - 1 Dec 2013

Lee Ching-Hung, Chen Yen-Wei, Huang Yun-Tzu, Pan Yih-Jiuan, Lee Chien-Hsien, Lin Shih-Ming, Huang Lin-Kun, Lo Yueh-Yu, Huang Yu-Fen, Hsu Yu-Di, Yen Shih-Chung, Hwang Jenn-Kang, Pan Rong-Long

Abstract excerpt

H⁺-translocating pyrophosphatase (H⁺-PPase, EC 3.6.1.1) plays an important role in acidifying vacuoles by transporting protons across membranes at the expense of pyrophosphate (PP(i)) hydrolysis. Vigna radiata H⁺-PPase (VrH⁺-PPase) contains 16 transmembrane helices (TMs). The hydrophobicity of TM3 is relatively lower than that of most other TMs, and the amino acids in this TM are highly conserved in plants....

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PMID: 24121627
DOI: 10.1007/s00232-013-9599-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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