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Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis?

Tuberculosis (Edinburgh, Scotland) - 1 Nov 2013

Goldman Robert C

Abstract excerpt

High through put screening (HTS) was extensively used in attempts to discover new TB drugs from libraries of pure small molecule compounds many of which complied with the rule of five. Coupled with new methods for determining the target of lead compounds by resistance selection followed by genome sequencing, screening for growth inhibitors led to several recent reports of compounds linked to specific...

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PMID: 24119636
DOI: 10.1016/j.tube.2013.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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