Article
Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 (polycystin-2)-dependent manner.
British journal of pharmacology - 1 May 2014
Waheed A, Ludtmann M H R, Pakes N, Robery S, Kuspa A, Dinh C, Baines D, Williams R S B, Carew M A
Abstract excerpt
BACKGROUND AND PURPOSE: Identifying and characterizing potential new therapeutic agents to target cell proliferation may provide improved treatments for neoplastic disorders such as cancer and polycystic diseases. EXPERIMENTAL APPROACH: We used the simple, tractable biomedical model Dictyostelium to investigate the molecular mechanism of naringenin, a dietary flavonoid with antiproliferative and chemopreventive...
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