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A key role for EZH2 in epigenetic silencing of HOX genes in mantle cell lymphoma

9 Oct 2013

Abstract excerpt

The chromatin modifier EZH2 is overexpressed and associated with inferior outcome in mantle cell lymphoma (MCL). Recently, we demonstrated preferential DNA methylation of HOX genes in MCL compared with chronic lymphocytic leukemia (CLL), despite these genes not being expressed in either entity. Since EZH2 has been shown to regulate HOX gene expression, to gain further insight into its possible role in...

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PMID: 24107828
DOI: 10.4161/epi.26546

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