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Article

SOCS and Herpesviruses, With Emphasis on Cytomegalovirus Retinitis

11 Apr 2019

Abstract excerpt

Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomegalovirus, can manipulate expression of...

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PMID: 31031749
DOI: 10.3389/fimmu.2019.00732

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