Article
Genetic regulation of dihydropyrimidinase and its possible implication in altered uracil catabolism.
Pharmacogenetics and genomics - 1 Nov 2007
Thomas Holly R, Ezzeldin Hany H, Guarcello Vincenzo, Mattison Lori K, Fridley Brooke L, Diasio Robert B
Abstract excerpt
OBJECTIVE: Dihydropyrimidine dehydrogenase (DPD) deficiency accounts for approximately 43% of grade 3-4 toxicity to 5-fluorouracil. There, however, remain a number of patients presenting with 5-fluorouracil-associated toxicity despite normal DPD enzyme activity, suggesting possible deficiencies in dihydropyrimidinase (DHP), encoded by the DPYS gene, and/or beta-ureidopropionase (BUP-1), encoded by the UPB1 gene....
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