Article
A systematically combined genotype and functional combination analysis of CYP2E1, CYP2D6, CYP2C9, CYP2C19 in different geographic areas of mainland China--a basis for personalized therapy.
PloS one - 1 Jan 2013
Wu Zhenqiang, Zhang Xiaoqing, Shen Lu, Xiong Yuyu, Wu Xi, Huo Ran, Wei Zhiyun, Cai Lei, Qi Guoyang, Xu Qingqing, Cui Daxiang, Cui Donghong, Zhao Gengchun, He Lin, Qin Shengying
Abstract excerpt
The cytochrome P450 is the major enzyme involved in drug metabolism. Single CYP genotypes and metabolic phenotypes have been widely studied, but no combination analysis has been conducted in the context of specific populations and geographical areas. This study is the first to systematically anal...
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