Article
Molecular mechanism for an inherited cardiac arrhythmia.
Nature - 24 Aug 1995
Bennett P B, Yazawa K, Makita N, George A L
Abstract excerpt
In the congenital long-QT syndrome, prolongation of the cardiac action potential occurs by an unknown mechanism and predisposes individuals to syncope and sudden death as a result of ventricular arrhythmias. Genetic heterogeneity has been demonstrated for autosomal dominant long-QT syndrome by th...
Topics
- Action Potentials
- Animals
- Cells, Cultured
- Computer Simulation
- Humans
- Ion Channel Gating
- Long QT Syndrome
- Mutation
- Myocardium
- Oocytes
- Patch-Clamp Techniques
- Recombinant Proteins
- Sodium Channels
- Xenopus laevis