Article
Molecular mechanism for an inherited cardiac arrhythmia.
Nature - 24 Aug 1995
Bennett P B, Yazawa K, Makita N, George A L
Abstract excerpt
In the congenital long-QT syndrome, prolongation of the cardiac action potential occurs by an unknown mechanism and predisposes individuals to syncope and sudden death as a result of ventricular arrhythmias. Genetic heterogeneity has been demonstrated for autosomal dominant long-QT syndrome by the identification of multiple distinct loci, and associated mutations in two candidate genes have recently been...
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