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Article

Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and sinus node dysfunction.

Heart rhythm - 1 Jan 2016

Chen Jiarong, Makiyama Takeru, Wuriyanghai Yimin, Ohno Seiko, Sasaki Kenichi, Hayano Mamoru, Harita Takeshi, Nishiuchi Suguru, Yuta Yamamoto, Ueyama Takeshi, Shimizu Akihiko, Horie Minoru, Kimura Takeshi

Abstract excerpt

BACKGROUND: Long-QT syndrome (LQTS) is an inherited arrhythmia characterized by prolonged ventricular repolarization and malignant tachyarrhythmias. LQT1, LQT2, and LQT3 are caused by mutations in KCNQ1 (LQT1), KCNH2 (LQT2), and SCN5A (LQT3), which account for approximately 90% of genotyped LQTS patients. Most cardiac events in LQT1 patients occur during exercise, whereas patients with LQT3 tend to have...

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Source

Identifiers

PMID: 26282245
DOI: 10.1016/j.hrthm.2015.08.021

Genes

KCNH2
KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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