Article
Selective anticancer agents suppress aging in Drosophila.
Oncotarget - 1 Sept 2013
Danilov Anton, Shaposhnikov Mikhail, Plyusnina Ekaterina, Kogan Valeria, Fedichev Peter, Moskalev Alexey
Abstract excerpt
Mutations of the PI3K, TOR, iNOS, and NF-κB genes increase lifespan of model organisms and reduce the risk of some aging-associated diseases. We studied the effects of inhibitors of PI3K (wortmannin), TOR (rapamycin), iNOS (1400W), NF-κB (pyrrolidin dithiocarbamate and QNZ), and the combined effe...
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