Article
Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia.
American journal of human genetics - 3 Oct 2013
Rippey Caitlin, Walsh Tom, Gulsuner Suleyman, Brodsky Matt, Nord Alex S, Gasperini Molly, Pierce Sarah, Spurrell Cailyn, Coe Bradley P, Krumm Niklas, Lee Ming K, Sebat Jonathan, McClellan Jon M, King Mary-Claire
Abstract excerpt
Chimeric genes can be caused by structural genomic rearrangements that fuse together portions of two different genes to create a novel gene. We hypothesize that brain-expressed chimeras may contribute to schizophrenia. Individuals with schizophrenia and control individuals were screened genome wide for copy-number variants (CNVs) that disrupted two genes on the same DNA strand. Candidate events were filtered for...
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