Article
Association of CYP2D6 metabolizer status with mammographic density change in response to tamoxifen treatment.
Breast cancer research : BCR - 1 Jan 2013
Li Jingmei, Czene Kamila, Brauch Hiltrud, Schroth Werner, Saladores Pilar, Li Yi, Humphreys Keith, Hall Per
Abstract excerpt
INTRODUCTION: Not all breast cancer patients respond to tamoxifen treatment, possibly due to genetic predisposition. As tamoxifen-induced reductions in percent mammographic density (PMD) have been linked to the risk and prognosis of breast cancer, we conducted a candidate gene study to investigate the association between germline CYP2D6 polymorphisms and PMD change. METHODS: Baseline and follow-up mammograms were...
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