Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.

doi:10.1001/jama.2009.1420

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Article

Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.

JAMA - 7 Oct 2009

Schroth Werner, Goetz Matthew P, Hamann Ute, Fasching Peter A, Schmidt Marcus, Winter Stefan, Fritz Peter, Simon Wolfgang, Suman Vera J, Ames Matthew M, Safgren Stephanie L, Kuffel Mary J, Ulmer Hans Ulrich, Boländer Julia, Strick Reiner, Beckmann Matthias W, Koelbl Heinz, Weinshilboum Richard M, Ingle James N, Eichelbaum Michel, Schwab Matthias, Brauch Hiltrud

Abstract excerpt

CONTEXT: The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and endoxifen. The formation of active metabolites is catalyzed by the polymorphic cytochrome P450 2D6 (CYP2D6) enzyme. OBJECTIVE: To determine whether CYP2D6 variation is associated with clinical outcomes in women receiving adjuvant...

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Identifiers

PMID: 19809024
DOI: 10.1001/jama.2009.1420
PMCID: PMC3909953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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