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Article

Smad2-Dependent Downregulation of miR-30 Is Required for TGF-β-Induced Apoptosis in Podocytes

26 Sept 2013

Abstract excerpt

Transforming growth factors beta (TGF-β) are multi-functional cytokines capable of inducing apoptosis in epithelial cells, including glomerular podocytes. We and others have previously shown that podocyte-selective genetic deletion of the microRNA (miR)-processing enzyme, Dicer, caused glomerulosclerosis that was associated with podocyte apoptosis, and the miR-30 family was implicated in the process. Here, we...

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PMID: 24086574
DOI: 10.1371/journal.pone.0075572

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Smad2-Dependent Downregulation of miR-30 Is Required for TGF-β-Induced Apoptosis in PodocytesPMID 24086574Read ↗

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