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Article

GSTT1 null and MPO -463G>a polymorphisms and carboplatin toxicity in an Indian population.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013

Bag Arundhati, Pant Nirdosh Kumar, Jeena Lalit Mohan, Bag Niladri, Jyala Narayan Singh

Abstract excerpt

Carboplatin, a second generation platinum drug, is widely used to treat different types of cancers. However, myelosuppression remains a major consideration in its use. Genetic polymorphisms of enzymes involved in drug disposition can influence therapeutic outcome. The homozygous null deletion of phase II metabolic gene GSTT1 that abolishes its xenobiotic- detoxifying ability may be associated with carboplatin...

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Source

Identifiers

PMID: 24083736
DOI: 10.7314/apjcp.2013.14.8.4739

Genes

MPO
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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