Article
Thermal isomerization of the chromoprotein asFP595 and its kindling mutant A143G: QM/MM molecular dynamics simulations.
The journal of physical chemistry. B - 31 Oct 2013
Mironov Vladimir A, Khrenova Maria G, Grigorenko Bella L, Savitsky Alexander P, Nemukhin Alexander V
Abstract excerpt
Chromoprotein asFP595 and its A143G variant called kindling fluorescent protein (KFP) are among the chronologically first species for which trans-cis chromophore isomerization has been proposed as a driving force of photoswitching. In spite of long-lasting efforts to characterize the route between protein conformations referring to the trans and cis forms of the chromophore, the molecular mechanism of this...
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