Article
Nodule size is an independent predictor of malignancy in mutation-negative nodules with follicular lesion of undetermined significance cytology.
Surgery - 1 Oct 2013
Mehta Rohtesh S, Carty Sally E, Ohori N Paul, Hodak Steven P, Coyne Christopher, LeBeau Shane O, Tublin Mitchell E, Stang Michael T, Johnson Jonas T, McCoy Kelly L, Nikiforova Marina N, Nikiforov Yuri E, Yip Linwah
Abstract excerpt
BACKGROUND: In thyroid nodule fine-needle aspiration (FNA) cytology, the atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) category has a 5-15% malignancy risk that increases to 85-99% when mutation testing for BRAF, RAS, RET/PTC, or PAX8/PPARγ is positive. However, negative testing does not exclude malignancy. The study objective was to identify clinical and imaging...
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