Article

Staphylococcal aconitase expression during iron deficiency is controlled by an sRNA-driven feedforward loop and moonlighting activity

2024-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Pathogenic bacteria employ complex systems to cope with metal ion shortage conditions and propagate in the host. IsrR is a regulatory RNA (sRNA) whose activity is decisive for optimum S. aureus fitness upon iron starvation and for full virulence. IsrR down-regulates several genes encoding iron-containing enzymes to spare iron for essential processes. Here we report that IsrR regulates the trica...

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Literature Corpus work: d2edf263-681c-5da5-950f-091f52908aaf
DOI: 10.1101/2024.05.23.595409

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