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Article

Mouse Hoxa2 mutations provide a model for microtia and auricle duplication.

Development (Cambridge, England) - 1 Nov 2013

Minoux Maryline, Kratochwil Claudius F, Ducret Sébastien, Amin Shilu, Kitazawa Taro, Kurihara Hiroki, Bobola Nicoletta, Vilain Nathalie, Rijli Filippo M

Abstract excerpt

External ear abnormalities are frequent in newborns ranging from microtia to partial auricle duplication. Little is known about the molecular mechanisms orchestrating external ear morphogenesis. In humans, HOXA2 partial loss of function induces a bilateral microtia associated with an abnormal shape of the auricle. In mice, Hoxa2 inactivation at early gestational stages results in external auditory canal (EAC)...

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Source

Identifiers

PMID: 24067355
DOI: 10.1242/dev.098046

Genes

HOXA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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