Article
Mutational analysis of HOXA2 and SIX2 in a Bronx population with isolated microtia.
International journal of pediatric otorhinolaryngology - 1 Aug 2010
Monks Dennis C, Jahangir Arthee, Shanske Alan L, Samanich Joy, Morrow Bernice E, Babcock Melanie
Abstract excerpt
OBJECTIVE: Microtia is a developmental malformation of the external ear with genetic and environmental causes. The prevalence of microtia varies but several studies suggest increased incidence in Hispanic and African American populations. No causal genetic mutations have been identified in these populations. Mutations in the homeobox gene HOXA2 caused microtia in a single Iranian family. Another homeobox gene,...
Topics
- Black or African American
- Cohort Studies
- Congenital Abnormalities
- Congenital Microtia
- DNA Mutational Analysis
- Ear
- Ear, External
- Female
- Genetic Predisposition to Disease
- Hispanic or Latino
- Homeodomain Proteins
- Humans
- Incidence
- Infant, Newborn