Article
Genetic variants in microRNAs and breast cancer risk in African American and European American women.
Breast cancer research and treatment - 1 Oct 2013
Yao Song, Graham Kelly, Shen Jie, Campbell Lara E Sucheston, Singh Prashant, Zirpoli Gary, Roberts Michelle, Ciupak Gregory, Davis Warren, Hwang Helena, Khoury Thaer, Bovbjerg Dana H, Jandorf Lina, Pawlish Karen S, Bandera Elisa V, Liu Song, Ambrosone Christine B, Zhao Hua
Abstract excerpt
MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. Single nucleotide polymorphisms (SNPs) in miRNAs and risk of breast cancer have been evaluated in populations of European or Asian ancestry, but not among women of African ancestry. Here we examined 145 SNPs in six miRNA processing genes and in 78 miRNAs which...
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